Mechanism Strength
94/100
GHRH analog → pituitary GH release
Metabolic Impact
89/100
↓ visceral fat • ↑ lipolysis • IGF-1 rise
Evidence Level
84/100
Strong clinical & research backing
Safety & Tolerability
80/100
Injection-site events • IGF-1 monitoring
PK / PD
Plasma t½ (SC)
GH Pulse Amplification
IGF-1 Elevation
Visceral Fat Reduction (Models)
Mechanism & Testing

Identity: Tesamorelin, a stabilized Growth Hormone–Releasing Hormone (GHRH) analog designed to enhance pulsatile GH secretion from the anterior pituitary.

Mode:
• Binds GHRH receptors on somatotrophs → stimulates cAMP/PKA pathway → GH pulse release.
• Downstream increase in IGF-1 drives lipolysis, fat oxidation, and improved metabolic profiles in research models.
• Studies examine reductions in visceral adipose tissue (VAT), enhanced mitochondrial activity, and improved protein synthesis.

Analytics: Purity via HPLC; LC-MS/MS identity; endotoxin screening via LAL; stability/appearance checks.
PD readouts: GH peak profiling, IGF-1 assays, DXA/MRI fat quantification, lipid panels, glucose/insulin curves.
Monitoring (research): injection-site irritation, IGF-1 ranges, glucose handling markers.

For educational/research-style product content. Not medical advice; not for human use.

Research Overview

Tesamorelin (10mg) is a synthetic growth hormone–releasing hormone (GHRH) analog studied for its ability to selectively stimulate pituitary GH secretion and downstream IGF-1 production in controlled research models. Literature evaluates its effects on lipid metabolism, visceral adipose tissue regulation, and metabolic-hormonal pathways linked to energy balance and cellular repair.

Mechanism of Action

GHRH Receptor Activation: Tesamorelin binds to the GHRH receptor on pituitary somatotrophs, stimulating pulsatile release of growth hormone.
GH → IGF-1 Axis: Resulting elevation of circulating GH and IGF-1 is studied for impacts on lipid oxidation, adipocyte metabolism, and anabolic/regenerative cellular signaling.
Metabolic Effects: Research focuses on reductions in visceral adipose tissue, changes in hepatic lipid content, modulation of glucose/lipid markers, and GH-driven metabolic adaptations in experimental conditions.

Research Applications

Visceral fat–reduction models • GH/IGF-1 axis investigation • Lipid-metabolism assays • Hepatic lipid and steatosis frameworks • Endocrine-metabolic pathway studies • Body-composition and calorimetry models • Pharmacokinetic and receptor-binding analyses of GHRH analogs.

Purity & Quality Assurance

Revitalized Health research peptides are produced under cGMP-aligned conditions with pharmaceutical-grade materials. Each Tesamorelin 10mg lot is confirmed at ≥99% purity via HPLC, with identity verified using LC-MS/MS. Lots undergo appearance checks, solubility verification, and microbial/endotoxin screening. Batch-specific Certificates of Analysis include full analytical documentation for traceability.

Storage & Stability

Store lyophilized Tesamorelin 10mg at 2–8 °C, protected from moisture and light. After reconstitution with bacteriostatic water, maintain at 2–8 °C and use within 20 days. Avoid repeated freeze–thaw cycles to preserve peptide stability and biological activity in research settings.

Research Disclaimer

For laboratory research use only. Not intended for human consumption, therapeutic use, or diagnostic application. Provided exclusively to qualified professionals conducting controlled scientific research.

Formulated for research use only. Purity, identity, and analytical results available per batch. Not medical advice.