5 Amino 1MQ

5-Amino-1MQ (10mg) is a small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor studied in metabolic and adipose-tissue research models. Scientific literature explores its role in regulating cellular energy balance, adipocyte metabolism, and NAD⁺-related signaling pathways involved in lipid storage and metabolic efficiency.

Per vial composition: 5-Amino-1MQ 10 mg (lyophilized powder for research use).

NNMT Inhibition: 5-Amino-1MQ is investigated for its ability to suppress NNMT activity, an enzyme linked to adipocyte differentiation and fat accumulation in metabolic tissues.
NAD⁺ Preservation: By limiting NNMT-mediated methylation of nicotinamide, research models evaluate potential increases in intracellular NAD⁺ availability and downstream effects on mitochondrial efficiency and cellular energy expenditure.
Metabolic Readouts: Common experimental endpoints include changes in adipocyte size, lipid-storage signaling, insulin-sensitivity markers, mitochondrial activity, and overall metabolic flux within adipose and hepatic systems.

Adipose-tissue and obesity models • Metabolic-efficiency and energy-expenditure studies • NAD⁺ and mitochondrial-function assays • Lipid-storage and adipocyte-differentiation frameworks • Glucose and insulin-signaling investigations • PK/PD profiling of NNMT inhibitors in preclinical systems.

Revitalized Health research compounds are produced under cGMP-aligned conditions with pharmaceutical-grade raw materials. Each 5-Amino-1MQ 10mg lot is verified at ≥99% purity via HPLC, with identity confirmed using LC-MS/MS. Lots undergo appearance assessment, solubility verification, and microbial/endotoxin screening to meet research-grade specifications. Batch-specific Certificates of Analysis provide full analytical documentation and traceability.

Store lyophilized 5-Amino-1MQ 10mg at 2–8 °C, protected from light and moisture. After reconstitution with a suitable laboratory solvent, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve compound stability and experimental consistency.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: 5-Amino-1MQ (5-Amino-1-methylquinolinium), a small-molecule compound researched for its role as an NNMT (nicotinamide N-methyltransferase) inhibitor.

Mode:
• Selectively inhibits NNMT, an enzyme involved in nicotinamide and methyl-donor metabolism.
• NNMT inhibition is associated with altered NAD⁺ availability, improved mitochondrial signaling, and shifts in adipocyte energy handling in preclinical models.
• Research focuses on effects related to fat accumulation, metabolic efficiency, insulin sensitivity, and cellular energy balance.

Analytics: HPLC purity confirmation; LC-MS identity; chemical stability profiling; residual-solvent and endotoxin screening where applicable.
PD readouts: NNMT activity assays, NAD⁺/NAM ratio analysis, adipocyte gene-expression profiling, mitochondrial respiration metrics, metabolic rate markers.
Monitoring (research): metabolic biomarkers, weight-change trends in models, and general tolerability parameters.