BRAIN STACK

BrainStack: Selank + Semax combines two research neuropeptides—Selank (a tuftsin-derived heptapeptide with anxiolytic and neuromodulatory properties) and Semax (ACTH(4–10) derivative with neurotrophic/neuromodulatory activity). The stack is used in experimental neuroscience to probe complementary pathways underlying stress regulation, attention, learning/memory, and cortical network plasticity in translational models.

Selank (Tuftsin analog): Literature examines modulation of GABAergic tone, serotonergic balance, and stress-axis readouts (anxiolytic profiles) with potential effects on cytokine signaling and neuroimmune crosstalk.
Semax (MEHFPGP): Associated with upregulation of neurotrophin-linked gene programs (e.g., BDNF pathways) and downstream MAPK/ERK, PI3K/Akt cascades that support synaptic protein expression and plasticity.
Rationale for Co-Administration: Selank’s anxiolytic neuromodulation + Semax’s neurotrophic signaling create a complementary framework for investigating attention control, learning performance, and resilience under cognitive or inflammatory stressors in preclinical paradigms.

Stress reactivity and anxiolytic profiling • Cortical plasticity and LTP/LTD assays • Attention and executive-function metrics • Neuroinflammation and redox-homeostasis models • Synaptic proteome/transcriptome readouts • Post-insult recovery frameworks integrating behavior and electrophysiology.

Revitalized Health peptides are produced under cGMP-aligned conditions with pharmaceutical-grade inputs. Each component (Selank and Semax) is confirmed at ≥99% purity by HPLC with identity verified via LC-MS/MS. Batches undergo appearance/solubility checks and microbial/endotoxin screening to research-grade specifications. Lot-specific Certificates of Analysis document analytical methods, parameters, and results.

Store lyophilized vials at 2–8 °C, protected from light and moisture. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve peptide integrity and receptor/target engagement fidelity.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: Semax (Met-Glu-His-Phe-Pro-Gly-Pro), ACTH(4-10) analog.
Mode: Upregulates neurotrophic programs (BDNF/TrkB axis), modulates catecholaminergic turnover, and induces anti-oxidative/anti-inflammatory transcripts in models; linked with attention/executive performance paradigms in regional studies.
Analytics: HPLC/LC-MS identity & purity; stability. PD: cognitive batteries (CPT/Trail Making), EEG spectral metrics, HRV stress markers; cytokine/BDNF panels. Monitoring: local nasal tolerability, BP/HR as applicable.

Identity: Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), tuftsin-derived heptapeptide.
Mode: Proposed allosteric influence on GABA_A tone, modulation of monoamine turnover, cytokine-balancing signatures (e.g., IL-6/TNF-α), and transcriptional effects including BDNF pathway support in preclinical work; anxiolytic-like profile with low sedation.
Analytics: HPLC/LC-MS identity & purity; peptide content/counter-ion; stability. PD: psychometric scales (STAI/HAM-A), EEG spectral metrics, HRV; cytokine panels and neurotrophic transcripts. Monitoring: local nasal tolerability, daytime alertness.