CEREBROLYSIN

Cerebrolysin is a standardized peptide and amino-acid fraction derived from neuroprotein hydrolysate, investigated for neurotrophic and neuroprotective properties in preclinical and translational research. Experimental use centers on synaptic plasticity, neuronal survival pathways, and circuit-level functional recovery models under ischemic, traumatic, or degenerative stress conditions.

Trophic Signaling: Literature explores BDNF/NGF-like activity with downstream Trk receptor–linked cascades engaging PI3K/Akt, MAPK/ERK, and CREB-dependent transcription to support neuronal survival and synaptogenesis.
Mito/Proteostasis: Reports assess attenuation of mitochondrial dysfunction, reduction of oxidative injury, and support of proteostasis/autophagy programs under cellular stress.
Inflammation & Excitotoxicity: Models examine modulation of microglial reactivity, cytokine tone, and glutamatergic excitotoxic pathways relevant to network stability and plasticity.
Functional Notes: Emphasis on dendritic spine density, synaptic protein expression, and electrophysiologic readouts that index circuit resilience and learning/memory paradigms.

Neuronal survival and plasticity assays • Ischemia/reperfusion and TBI models • Neuroinflammation and microglial phenotyping • Mitochondrial function and oxidative-stress studies • Synaptic proteome/transcriptome profiling • Behavioral and electrophysiologic endpoints in translational neuroscience.

Revitalized Health research products are prepared under cGMP-aligned conditions using pharmaceutical-grade inputs. Each lot of Cerebrolysin is verified for composition consistency and identity by chromatographic profiling (e.g., HPLC) with confirmatory mass analysis (LC-MS/MS). Appearance, pH/osmolality (where applicable), and microbial/endotoxin limits are assessed to research-grade specifications. Batch-level Certificates of Analysis document analytical methods and results.

Store sealed containers at 2–8 °C, protected from light and moisture. For aliquoted liquid research formats, avoid multiple freeze–thaw cycles; for lyophilized formats, reconstitute with bacteriostatic water, maintain at 2–8 °C, and utilize within 20 days. Record lot/expiry and maintain chain-of-custody for study traceability.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: Enzymatically derived low–molecular-weight neuropeptide and amino-acid fraction from porcine brain tissue.
Mode: Engages neurotrophic signaling (BDNF/TrkB-, NGF-related axes) and pro-survival cascades; supports synaptogenesis, dendritic spine stability, and metabolic resilience under excitotoxic/ischemic stress in models. Reported functional domains include anti-apoptotic signaling, microglial modulation, and improved neuroplasticity during rehab paradigms.
Analytics: Fingerprint profiling by HPLC/LC-MS of peptide fraction; amino-acid composition; sterility (USP <71>), endotoxin (USP <85>), osmolality and pH. PD readouts: stroke/TBI scales (NIHSS, mRS, Barthel), global cognition (MMSE/MoCA), psychometrics, EEG/fMRI connectivity, and serum biomarkers (BDNF, NSE). Monitoring: infusion-site reactions, BP/HR, dizziness/headache; hypersensitivity history.