MOTS-C

MOTS-C (Mitochondrial ORF of the 12S rRNA type-C) is a mitochondria-encoded regulatory peptide investigated for its role in cellular energy homeostasis and adaptive stress signaling. In research models, MOTS-C modulates metabolic gene programs and supports studies of nutrient sensing, insulin signaling, and exercise-like stress responses across skeletal muscle, hepatic, and adipose systems.

Origin: Short ORF within mitochondrial 12S rRNA yields a 16-aa peptide implicated in mito-nuclear communication.
Pathways: Activation of AMPK and downstream effectors (e.g., ACC phosphorylation) → enhanced fatty-acid oxidation, glucose uptake, and mitochondrial efficiency in preclinical paradigms.
Gene Programs: Under metabolic stress, MOTS-C has been reported to translocate to the nucleus and influence stress-response transcriptional networks that coordinate substrate utilization and proteostasis.
Functional Notes: Research focuses on insulin signaling, GLUT4 trafficking, and attenuation of nutrient-excess stress signals without directly acting as a classic incretin or adrenergic agent.

AMPK-centered metabolic control • Substrate switching (lipid ↔ carbohydrate) • Skeletal-muscle performance and mitochondrial biogenesis assays • Hepatic glucose production studies • Adipocyte lipid handling • Mito-nuclear stress communication and redox homeostasis.

Revitalized Health peptides are produced under cGMP-aligned conditions with pharmaceutical-grade inputs. Each MOTS-C lot is confirmed at ≥99% purity by HPLC, with structure/identity verified via LC-MS/MS. Lots undergo appearance/solubility checks and microbial/endotoxin screening to research-grade specifications. Batch-level Certificates of Analysis document analytical methods, parameters, and results.

Store lyophilized vials at 2–8 °C, protected from light and moisture. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve peptide integrity and receptor/target engagement fidelity.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.