MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16–amino-acid peptide encoded by mitochondrial DNA. It is investigated in preclinical models for its role in cellular energy regulation, including modulation of AMPK activity, nutrient-sensing pathways, and the integrated stress response. Researchers use MOTS-c to study mitochondrial–nuclear signaling (“retrograde” signaling) and its effects on glucose and lipid metabolism.
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16–amino-acid peptide encoded by mitochondrial DNA. It is investigated in preclinical models for its role in cellular energy regulation, including modulation of AMPK activity, nutrient-sensing pathways, and the integrated stress response. Researchers use MOTS-c to study mitochondrial–nuclear signaling (“retrograde” signaling) and its effects on glucose and lipid metabolism.