MT2

Melanotan II (MT-II) is a synthetic cyclic peptide analog of the endogenous melanocortin hormone α-MSH. It is studied in controlled research models for its ability to activate melanocortin receptors (primarily MC1R, MC3R, MC4R, and MC5R). Investigations explore its influence on pigmentation pathways, energy balance, appetite signaling, and neuroendocrine response patterns.

MC1R Stimulation: Activation is studied for upregulating eumelanin production and increasing melanogenesis in skin and follicular melanocytes.
MC3R / MC4R Pathways: Research explores central effects on energy homeostasis, appetite modulation, and sexual-behavior circuitry in hypothalamic and limbic networks.
Neuropeptide & Signaling Effects: Experimental endpoints include alterations in melanocyte activity, melanin output, food-intake patterns, neuropeptide expression, and receptor-density response curves across melanocortin subtypes.

Pigmentation and melanocyte-function modeling • UV-response studies • Melanocortin-receptor pathway assays • Appetite/energy-regulation frameworks • Behavioral neuroendocrine models • Receptor-selectivity and dose–response investigations • PK/PD evaluation of α-MSH analogs.

Revitalized Health research peptides are produced under cGMP-aligned conditions with pharmaceutical-grade raw materials. Each Melanotan II lot is verified at ≥99% purity by HPLC, with peptide identity confirmed via LC-MS/MS. Every batch undergoes visual inspection, solubility verification, and microbial/endotoxin screening to ensure research-grade validity. Certificates of Analysis include full analytical documentation for traceability.

Store lyophilized Melanotan II vials at 2–8 °C, shielded from moisture and light. After reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve structural integrity and receptor-interaction fidelity in experimental settings.

For laboratory research use only. Not intended for human consumption, therapeutic use, or diagnostic application. Supplied only to qualified professionals conducting controlled scientific research.

Identity: Melanotan II, a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH) with affinity for melanocortin receptors, particularly MC1R on melanocytes.
Mode: MC1R activation on epidermal melanocytes increases intracellular cAMP → upregulation of tyrosinase and related melanogenic enzymes → enhanced eumelanin production and melanosome transfer to keratinocytes. Experimental frameworks evaluate UV-dose sparing, pigment-distribution patterns, and phototype shifts under controlled conditions.
Analytics: Purity by HPLC; identity by LC-MS/MS; sequence confirmation; endotoxin via LAL. PD readouts: melanin content assays, tyrosinase activity, cAMP signaling in melanocyte cultures, imaging/reflectance spectroscopy for skin-darkening indices, lesion mapping for nevi/freckle change. Monitoring (research): flushing, GI effects, blood pressure/heart rate, evolution of pigmented lesions, overall UV exposure context.