N ACETYL SEMAX AMIDATE

N-Acetyl Semax Amidate (NAS-A) is a structurally modified analog of Semax that incorporates N-terminal acetylation and C-terminal amidation to enhance peptide stability and resist exopeptidase degradation in research systems. NAS-A is utilized in experimental neuroscience to interrogate neuromodulation, synaptic plasticity, and stress-response pathways with an emphasis on cortical network function and cognitive process readouts in preclinical models.

Design: N-terminal acetylation and C-terminal amidation aim to improve metabolic stability, receptor engagement windows, and proteolytic resistance versus the parent sequence.
Neurotrophic Programs: Literature on Semax-class peptides describes upregulation of neurotrophin-linked gene expression (e.g., BDNF-associated pathways) with downstream MAPK/ERK and PI3K/Akt cascades that support synaptic protein expression and plasticity indices.
Neurotransmission: Experimental work evaluates modulation of monoaminergic tone and glutamatergic balance, with effects tracked across cortical excitability and attention metrics.
Functional Notes: NAS-A is explored for its enhanced stability profile to enable extended observation windows in vitro and in vivo research paradigms.

Synaptic plasticity and LTP assays • Learning/memory and attention paradigms • Cortical network oscillations and sensory processing • Oxidative-stress and neuroinflammation models • Recovery frameworks after experimental insult with proteostasis and mitochondrial readouts.

Revitalized Health peptides are produced under cGMP-aligned conditions using pharmaceutical-grade inputs. Each NAS-A lot is confirmed at ≥99% purity by HPLC with structure/identity verified by LC-MS/MS. Lots undergo appearance and solubility checks, with microbial/endotoxin screening to research-grade specifications. Batch-level Certificates of Analysis document analytical methods and validated results.

Store lyophilized vials at 2–8 °C, protected from light and moisture. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve peptide integrity and target-engagement fidelity.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: N-Acetyl Semax Amidate (NAS-A), an N-terminally acetylated and C-terminally amidated ACTH(4-10) analog.
Mode: Retains Semax core motifs with modifications that enhance protease resistance and metabolic stability, supporting longer residence time after intranasal delivery. Reported to upregulate neurotrophic programs (BDNF/TrkB), modulate monoamine turnover, and engage anti-oxidative/anti-inflammatory gene signatures in preclinical models—aimed at attention, working memory, and stress resilience profiles.
Analytics: Identity/purity by HPLC and LC-MS; peptide content & counter-ion profile; accelerated/real-time stability and peptidase-resistance assays. PD readouts: cognitive batteries (CPT, Trail Making), EEG spectral metrics, HRV stress markers; serum/plasma BDNF and cytokine panels in exploratory settings. Monitoring: local nasal tolerability, daytime alertness, BP/HR as applicable.