SELANK

Selank is a synthetic analog of the human tetrapeptide tuftsin, developed to study anxiolytic, neuroprotective, and cognitive-modulating effects in controlled research models. It is frequently utilized to examine the regulation of GABAergic signaling, neurotransmitter balance, and adaptive stress-response mechanisms in neurobehavioral and cognitive assays.

Neurotransmission: Selank modulates GABA receptor expression and signaling, stabilizing inhibitory tone within cortical and limbic networks. Studies suggest normalization of serotonin metabolism and modulation of monoaminergic pathways related to mood regulation.
Neuroimmune Regulation: Research explores Selank’s role in cytokine modulation and neuroimmune balance, contributing to stress resilience and reduction of systemic inflammatory markers.
Cognitive & Behavioral Pathways: Literature indicates enhanced attention, focus, and cognitive performance through modulation of neuropeptide and neurotransmitter cross-talk.

Anxiety and stress reactivity studies • Neurotransmitter regulation and synaptic plasticity • Cognitive performance and memory retention models • Cytokine modulation and neuroimmune research • Comparative behavioral assays in stress adaptation and learning paradigms.

Revitalized Health peptides are synthesized under cGMP-aligned manufacturing protocols using pharmaceutical-grade materials. Each Selank lot is verified for ≥99% purity via HPLC and LC-MS/MS identity confirmation. Every batch undergoes sterility, solubility, and endotoxin testing to ensure research-grade compliance, with full Certificates of Analysis issued per lot.

Store lyophilized Selank at 2–8 °C, protected from light and moisture. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid freeze–thaw cycles to preserve molecular structure and receptor activity.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous tetrapeptide tuftsin.
Mode: Neuromodulatory peptide with proposed actions on GABAergic tone (allosteric influence at GABA_A receptor sites in models), modulation of monoamine turnover (serotonergic/dopaminergic pathways), inhibition of enkephalin-degrading activity in some assays, anti-inflammatory cytokine balancing (e.g., IL-6/TNF-α signatures), and transcriptional effects including BDNF pathway support in preclinical work. Demonstrates anxiolytic-like effects without classic sedative impairment in experimental settings.
Analytics: Identity/purity by HPLC and LC-MS; peptide content and counter-ion profile; stability (accelerated/real-time). PD readouts: EEG spectral metrics, psychometric scales (e.g., HAM-A, STAI), eye-blink startle or HRV stress paradigms; cytokine panels; RT-qPCR for neurotrophic transcripts. Monitoring: local nasal tolerability, daytime alertness, BP/HR as applicable.