SEMAX

Semax is a synthetic heptapeptide derivative of the ACTH(4–10) fragment (sequence MEHFPGP) investigated for neurotrophic, neuromodulatory, and neuroprotective properties. In research models, Semax is utilized to explore synaptic plasticity, cognitive-process modulation, stress-resilience pathways, and cerebrovascular–neural coupling, with attention to learning/memory readouts and cortical network dynamics.

Neurotrophin Signaling: Literature examines Semax-associated upregulation of neurotrophin pathways (e.g., BDNF-linked gene programs) with downstream MAPK/ERK and PI3K/Akt activity that supports synaptic protein expression and plasticity.
Neurotransmission: Reports evaluate modulation of monoaminergic tone (dopaminergic/serotonergic), glutamatergic balance (AMPA/NMDA), and cortical excitability parameters in translational paradigms.
Stress/Inflammation: Investigations probe antioxidant and anti-inflammatory responses, including redox homeostasis markers and stress-responsive transcription that may influence neuronal survival under challenge.

Learning and memory assays • Synaptic plasticity and LTP readouts • Cortical network oscillations and attention metrics • Neuroinflammation and oxidative-stress models • Cerebrovascular–neural coupling and recovery paradigms following experimental insult.

Revitalized Health peptides are produced under cGMP-aligned conditions with pharmaceutical-grade inputs. Each Semax lot is confirmed at ≥99% purity by HPLC with structure/identity verified via LC-MS/MS. Lots undergo appearance and solubility checks, plus microbial/endotoxin screening to research-grade specifications. Batch-level Certificates of Analysis document analytical methods, parameters, and results.

Store lyophilized vials at 2–8 °C, protected from light and moisture. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and use within 20 days. Avoid repeated freeze–thaw cycles to preserve peptide integrity and receptor/target engagement fidelity.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: Semax (Met-Glu-His-Phe-Pro-Gly-Pro), ACTH(4-10) analog.
Mode: Upregulates neurotrophic programs (BDNF/TrkB axis), modulates catecholaminergic turnover, and induces anti-oxidative/anti-inflammatory transcripts in models; associated with attention/executive performance paradigms in regional studies.
Analytics: HPLC/LC-MS identity & purity; stability. PD: cognitive batteries (CPT/Trail Making), EEG spectral metrics, HRV stress markers; cytokine/BDNF panels. Monitoring: local nasal tolerability, BP/HR as applicable.