SLU-PP-332

SLU-PP-332 is an experimental research compound utilized to investigate cellular energy regulation, metabolic signaling, and stress-adaptation programs in preclinical systems. Current research explores its effects on pathways governing substrate utilization, mitochondrial efficiency, and exercise-like transcriptional responses in skeletal muscle and hepatic models. Pharmacological profiling remains an active area of investigation, and data are interpreted strictly within controlled laboratory settings.

Putative Biology: Studies evaluate SLU-PP-332 for modulation of energy-sensing networks and mitochondrial programs associated with adaptive metabolism.
Pathway Readouts (models): Investigations commonly monitor markers linked to AMPK activation, PGC-1α–associated transcription, fatty-acid oxidative flux, and mitochondrial respiratory capacity (e.g., OCR/ECAR profiling), while receptor selectivity and direct molecular targets continue to be characterized.
Functional Notes: Experimental designs focus on dose–response behavior, time-course kinetics, and reversibility, with attention to off-target signals and cytotoxicity thresholds.

Skeletal-muscle metabolic adaptation • Hepatic lipid handling and β-oxidation assays • Mitochondrial bioenergetics (Seahorse/Clark electrode) • Exercise-mimetic transcriptional programs • Nutrient stress and redox-homeostasis models • Comparative studies versus canonical AMPK/PGC-1α modulators.

Revitalized Health research compounds are produced under cGMP-aligned conditions with pharmaceutical-grade inputs. Each SLU-PP-332 lot is confirmed at ≥99% purity by HPLC with structure/identity assessed via LC-MS/MS. Lots undergo appearance and solubility checks and microbial/endotoxin screening to research-grade specifications. Batch-specific Certificates of Analysis document analytical methods, parameters, and results.

Store lyophilized material at 2–8 °C in a dry, light-protected environment. Following reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid repeated freeze–thaw cycles to preserve compound integrity and experimental reproducibility. Record lot/expiry and maintain chain-of-custody documentation for study traceability.

For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.

Identity: Small-molecule pan-estrogen-related receptor (ERRα/β/γ) agonist with exercise-mimetic transcriptional activity.
Mode: Stabilizes active ERR conformation → co-activation with PGC-1α → upregulates OXPHOS, β-oxidation, and mitochondrial biogenesis programs; increases oxidative muscle fiber signature and endurance in murine studies; improves metabolic indices in obese/aged mouse models.
Analytics: Identity/purity by HPLC/LC-MS; receptor binding/EC₅₀ via reporter assays; transcriptomics (ERR target gene panels), high-resolution respirometry (OCR, spare capacity), acyl-carnitine profiling, and in vivo indirect calorimetry. Monitoring (research): body temperature/thermogenesis, activity/EE by CLAMS, lipid/glucose panels; observe for stimulatory or GI effects depending on vehicle.