SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) engineered to localize to the inner mitochondrial membrane through electrostatic interaction with cardiolipin. Research applications focus on mitochondrial protection, bioenergetic restoration, and reduction of oxidative injury in metabolic, ischemic, and age-related experimental models. The 50 mg format supports high-precision dosing for in-vitro and translational investigations.
Target: Cardiolipin within the inner mitochondrial membrane (IMM). Mode: SS-31 binds anionic phospholipids, stabilizing cristae curvature and respiratory-chain supercomplexes, improving electron transport efficiency, and reducing electron leakage and ROS generation. Downstream Effects: ↑ ATP synthesis, ↓ mitochondrial permeability transition, and attenuation of cytochrome-c release. Functional Metrics: Studies report improved oxidative phosphorylation coupling, reduced lipid peroxidation, and normalization of ΔΨm (membrane potential) across multiple cell types.
Mitochondrial dysfunction and oxidative-stress models • Ischemia/reperfusion and hypoxia studies • Bioenergetic flux and respiration assays (Seahorse/OCR) • Cardiolipin–protein interaction mapping • Aging and neurodegeneration research • Comparative peptide-mitoprotection profiling.
Revitalized Health peptides are synthesized under cGMP-aligned conditions with pharmaceutical-grade inputs. Each SS-31 lot is confirmed at ≥99 % purity by HPLC and validated by LC-MS/MS. Batches undergo solubility, appearance, and endotoxin testing to research-grade specifications. Each release includes a detailed Certificate of Analysis documenting analytical parameters and verification data.
Store lyophilized SS-31 at 2–8 °C, protected from light and moisture. After reconstitution with bacteriostatic water, maintain at 2–8 °C and utilize within 20 days. Avoid freeze–thaw cycles to preserve tertiary structure and binding affinity. Handle using low-binding plastics or borosilicate glassware to prevent surface adsorption.
For laboratory research use only. Not intended for human consumption, therapeutic, or diagnostic application. Supplied exclusively to qualified professionals conducting controlled scientific investigations.
Formulated for research applications. Purity, identity, and lot analytics available per batch. Not medical advice.
Target: Cardiolipin (inner mitochondrial membrane).
Mode: Stabilizes cristae & ETC supercomplexes → ↑ ATP synthesis, ↓ oxidative stress under metabolic/ischemic stress.
Analytics: HPLC ≥99%, LC-MS; mitochondrial respiration, ΔΨm (TMRE/JC-1), ROS (MitoSOX); in-vivo ATPmax where applicable.
Benchmarked against top-tier mitochondrial products for site education. Not medical advice.